1 Roanoke Colony
In 1587 121 colonists led by John White arrived on Roanoke Island in present day North Carolina to establish a colony. As tensions mounted with the native population, however, John White returned to England in order to solicit reinforcements. When he returned several years later the settlement was deserted with no signs of a struggle and no remains to be found anywhere. The settlement became known as the Lost Colony and none of its members were ever seen again.